Human C5a / Complement 5a Protein 10604-HNAE from Sino Biological, Inc.

Product Specs
ItemHuman C5a / Complement 5a Protein
CompanySino Biological, Inc.
Price Supplier Page View Company Product Page
Catalog Number10604-HNAE
Conjugate/TagUnconjugated
Purity> 94 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human C5a consists of 74 amino acids and has a predicted molecular mass of 8.3 kDa which is also estimated by SDS-PAGE
SpeciesHuman
Molecule NameC5
Source/Expression SystemE. coli
ActivityMeasured by its ability to induce N-acetyl-β-D-glucosaminidase release from differentiated U937 human histiocytic lymphoma cells. The ED50 for this effect is typically 5-15 ng/mL
FormatLyophilized from sterile PBS, pH 7.4
NCBI Full Gene Namecomplement C5
NCBI Gene AliasesC5D, C5a, C5b, CPAMD4, ECLZB

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Sino Biological, Inc.

1400 Liberty Ridge Drive

Suite 101

Wayne, PA 19087

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: http://www.sinobiological.com/

(1) Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activationSTAR protocolsNovember 29, 2023Li XX, Woodruff TM.proteins","Chemicals, peptides, and recombinant proteins" ,, Recombinant human C5a,Sino Biological,10604-HNAE Purified human C3a,Merck,US1204881 "C5aR1 antagonists (PMX53, PMX205, JPE-1375)","Synthesized in-house

(2) Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptorsMolecular cellNovember 18, 2021Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, et al.

(3) C5a Activates a Pro-Inflammatory Gene Expression Profile in Human Gaucher iPSC-Derived MacrophagesInternational journal of molecular sciencesSeptember 14, 2021Serfecz JC, Saadin A, Santiago CP, Zhang Y, Bentzen SM, Vogel SN, Feldman RA.replaced with medium containing 3 nM recombinant human C5a (rC5a) (Sino Biological, Beijing, China #10604-HNAE). After 8 h, macrophage culture supernatants were collected and assayed for the indicated cytokines

(4) Preterm Birth Is Associated With Immune Dysregulation Which Persists in Infants Exposed to Histologic ChorioamnionitisFrontiers in immunologyJanuary 1, 2021Sullivan G, Galdi P, Borbye-Lorenzen N, Stoye DQ, Lamb GJ, Evans MJ, Skogstrand K, Chandran S, Boardman JP.of 20:1. The following calibrators were used: C3: #PSP-109 (Nordic Biosite, Copenhagen, DK), C5a: #10604-HNAE (Sino Biological), C9: #F21XZ (from R-plex kit, MSD), MMP-9: #911-MP, RANTES: #278-RN and CRP: #1707-CR/CF

(5) Interleukin-8 dysregulation is implicated in brain dysmaturation following preterm birthBrain, behavior, and immunityNovember 1, 2020Sullivan G, Galdi P, Cabez MB, Borbye-Lorenzen N, Stoye DQ, Lamb GJ, Evans MJ, Quigley AJ, Thrippleton MJ, Skogstrand K, et al.

(6) Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific ProgrammingCell reportsNovember 19, 2019Hoogendijk AJ, Pourfarzad F, Aarts CEM, Tool ATJ, Hiemstra IH, Grassi L, Frontini M, Meijer AB, van den Biggelaar M, Kuijpers TW.

(7) Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonistsScientific reportsApril 20, 2016Seow V, Lim J, Cotterell AJ, Yau MK, Xu W, Lohman RJ, Kok WM, Stoermer MJ, Sweet MJ, Reid RC, et al.

(8) Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5aJournal of immunology (Baltimore, Md. : 1950)October 15, 2013Seow V, Lim J, Iyer A, Suen JY, Ariffin JK, Hohenhaus DM, Sweet MJ, Fairlie DP.

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Human C5a / Complement 5a Protein

Human C5a / Complement 5a Protein from Sino Biological, Inc.

Description

Sino Biological, Inc.

Citations (8)

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Human C5a / Complement 5a Protein from Sino Biological, Inc.

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